FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Powder physical properties, pharmaceutical drugs, excipients, starch-maize, sodium-montmorillonite and Kaolinite. X-ray diffractogram (XRD), X-ray Fluorescence (XRF).
The need to maximize therapeutic activity and at the same time minimizing negative side effects have continuously led researchers to development new controlled drug delivery systems. The selected clay minerals were obtained from Okada Town and Usen Community, about 28km and 32km from Benin City, Edo State, Southwestern Nigeria, respectively; having geographical coordinates of latitude 60 40l/ - 60 45l/ N and longitudes 50 20l/ - 50 25l / E, the area is characterized by torrential rainfall, high surface runoff due to their low infiltration rates and high canopy trees. The inert samples were subjected to XRD analysis to ascertain the mineralogy compositions; and XRF analysis gave the elemental compositions from which the inherent constituents were predominant. They were purified by washing in aqueous 0.1M NaCl solutions; the resulting suspensions were sieved and dried at 35°C in an oven. The powder maize-starch was prepared from crushed grains and the slurry was sieved and dried at 35°C in an oven. The angle of repose, true density, powder porosity, bulk density, tapped density, Hausner’s ratio powder retention capacity, swelling capacity, and pH were experimentally carried out to determine the physical properties of the powder: such as swell ability, flowability, void space, capillary action, acidity, and alkalinity; powder physical properties obtained for sodium-montmorillonite (Na-MMT) and Kaolinite were compared with those of reference standard of maize-starch (MS). The data revealed that Na-MMT is more effective excipient for formulation of pharmaceutical drugs than Kaolinite.
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